Hey, I don't think you have her on the correct dose of Baytril, but because she is on 2 other meds, there could be a synergistic effect that I am unfamiliar with. But 0.1ml only once a day just seems to be very low, especially when I always see that antibiotic at 2X/day. So that would mean unless your Baytril is twice as long acting, as the liquid I am familiar with, your dose is only effective for 12 hours, and that is seriously not good. That said, you might want to look into it. What is the mg/mL of yout Baytril? As for whether or not she is experiencing a high amount of discomfort or is in any distress, you can get an idea by how she's behaving compared to like about 6 months ago, how she's eating and drinking, if she is active or not, wants to socialize with you or other rats, those sorts of things. Personally, if my rats are I'll with advanced URI issues, and 2+ years old, and are behaving much differently or not active or sociable, but are still eating and drinking and NOT gasping, then I allow them to continue their treatment plan until they either stip eating and drinking, at which point I try pushing Ensure to them just in case it's a temporary flare up, or, experience any gasping whatsoever, at which time I monitor them very closely, give the last ditch effort meds, like nebulizer, and any other bronchial dialators (sp?) and if there improvement, I start anti-inflammatory med(s) and steroids after conferring with my vet, whom I have already called to make aware of my probable forthcoming emergency visit. Often the gasping will subside, but just as often it will continue to rear its uglt head, especially if they become stressed, excited, winded, exhausted, or frightened. You absolutely must keep them calm and relaxed. No overly active cage mates, no loud noises, no stressful situations. Anyway, usually they can survive (key word here since their lifestyle has taken an obvious blow) for days, weeks, even months. I just buried a foster who had reached this point, list tons of weight (because I inexcusably missed it) and stopped eating. I put him on Ensure at all times (filled his bowl whenever it was empty) and several more meds, and he gained most of his weight back and learned to live very sedentary and still holds the record at almost 6 months without solid food or water, just Ensure and meds!!! He did very little but for when I gave him loving on time every day for as long as I could. Eventually his breathing became too siffidiff, he couldn't get enough oxygen for basic automatic bodily functions, and I had to let him go, but he never did lose his weight again since he drank tons of Ensure and ate very small amounts of soggy foods. His gasping only came back a few days prior to my having him PTS, and once the customary 24 hours of rebounding allotment time passed and then a Sunday passed with no improvement, and consideicon he had been barely living for months already, I did not waste any time getting him PTS to avoid a horrible suffocation. He actually did get frantic on Sunday night, so I stayed up with him keeping him as calm as possible, but he was gasping pretty bad and had a hard time relaxing. He eventually fell asleep with his head raised up and propped up on a food of blanket to help him get air in, and I was at my vets waiting for them to open the doors, which they already knew and had arrived early for me. Ok, I've rambled on much too long now. But yeah, advanced URI is a horrible disease, you gotta monitor them 24/7, and as soon as you see the telltale raised head and open mouth breathing, you know it's nearly always the beginning of the end when they're over 2 years of age.But they can definitely live for awhile more quite comfortably provided you are able to give them intense hospice care and be around more often than not to be sure they don't go into respiratory distress when you aren't around. It's such a horrifying death,cyou just can't chance it unless you can 100% be available for them. Best luck to your girl if she's still with you.