baytril and Enalapril mixing.

[hopefloats]

My meds came and boy they gave me refills LOL

i have 90 more pills by this time next year of my baytril and 600 more on the enalapril LOL holy moly!

so my baytril is 136mg and my enalapril is 20mg per pill I need some mixing help how much liquid with each pill and also around about dosing for each with a 450 g rat.

I can figure the rest out but the mixing confuses me I swear one day I will understand. well ok probably not.

 

[jorats]

Math alert!
I'll pass on this question. :nod:

 

[hopefloats]

I think I got part of it. I went back to my other post Jenny was kind enough to leave the math in there

so it is a 136mg pill divided by the amount of liquid which in my case i am using the 5 ml.

that gave the 27.2 but the problem is, i am not sure how to figure dosing from there LOL

I just want to test it out, so i was gonna mix the pills up today

I still need it for the enalpril which is 20mg pill. I know with 4 2.5 mg pills i used 2 ccs of liquid so i am assuming with 20mg i can use 4 ccs. But again i cannot figure out the dosing again LOL

 

[hopefloats]

If i use 6ml of liquid for the baytril then it is pretty close to the 22.7 so I can use that instead. Now the heart meds worry me so I dont want to cause any problems with that so i will wait on that answer

 

[Joanne]

136mg pill divided by the amount of liquid which in my case i am using the 5 ml.

that gave the 27.2 but the problem is, i am not sure how to figure dosing from there LOL

So the concentration of the drug is 27.2 mg/ml.

Now you need to look up the recommended amount of drug to give your rat.
Enalapril drug range is 10 mg/lb up to 10 mg/kg.
So take the lower range, 10 mg/lb which = 10 mg/454g which = 0.022mg/g of Enalapril.
So you want to give your rat 0.022mg/g of drug.

I did all the math out on another thread (last post on pg 1 and first post on pg 2.) See if it makes sense:
viewtopic.php?f=20&t=30088&hilit=dosage&start=0

ETA - the drug there was different, but the math is the same.

ETA 2 - To simplify, the amount of drug your rat needs is 450g x 0.022mg/g which will give you the mg of drug. Then skip to the next page. Gotta make sure your units are the same...

 

[hopefloats]

that dosing is what confuses me. I will look it over again.

 

[lilspaz68]

On the fly...

Baytril 136 mg pill with 5 mls = 27.2 mg/ml - dose of .17 cc BID

Enalapril 20 mg pill with 4 ml's = 5 mg/ml - dose of .05 cc BD

for enalapril I convert to .55 mg/kg BID

http://ratguide.com/meds/cardiovascular ... aleate.php

Dosing Recommendations:

or

0.25 mg/lb, PO, BID 3

or

0.5 mg/kg to 1 mg/kg, PO, q24hrs 34

 

[Joanne]

Sorry, had to go back to work!

450g rat x 0.022 mg/g = 9.9 mg of drug

You made up your drug into a concentration of 27.2 mg/ml. So we want to know how many ml's we need to give us 9.9 mg of drug. This is where algebra comes in handy! So the number of ml's will be X, solve for X: (cross multiply)

27.2 mg = 9.9 mg
1 ml............X ml (stupid ...... are for spacing)

27.2 X = 9.9 x 1

27.2 X = 9.9

X = 0.36 ml

So to recap, if you make up a solution of 136 mg pill into 5 ml of water AND
you have a rat of 450 mg AND
you want a dosage of 10 mg/lb,
then the amount you would give is 0.36 ml.

The dosage of 10 mg/lb is the high end, not the low end.